Bodhi and Hypertrophic Osteodystrophy

Treatment for Hypertrophic Osteodystrophy in Weimaraners

When Dr. Noa Safra asked us to help her educate owners of Weimaraners afflicted with a disease called Hypertrophic Osteodystrophy (HOD), we agreed enthusiastically.

We don’t think it’s hyperbole to say she saved Bodhi’s life.

Working with her to create a support network for others facing HOD was the least we could do.

We hope Bodhi’s story gives people hope.

Bodhidharma Beasley-Sheer joined our family in New York City on June 26, 2012. Bodhi came from a reputable breeder, from a litter of nine. He descends from one of the show lines. His father had competed at the Westminster Kennel Club Dog Show two years earlier.

Bodhi on his First Visit to the Beach, a Few Weeks After he Joined our Family

Several weeks after we got Bodhi, he came down with a persistent case of diarrhea. We weren’t particularly alarmed, puppies get the runs all the time, but to be on the safe side, we took him to our local veterinarian. She conducted a routine examination but could not find any obvious underlying cause.

The next day he seemed very tired and wasn’t drinking much. Later that afternoon we noticed that Bodhi was not placing his left foot down. He had just walked through some dried-up, prickly holly leaves on the ground so we thought maybe he’d irritated his paw pad somehow. But he continued to be lethargic for the rest of the day, which concerned us. We decided to call our vet, she told us to monitor him

The following morning he was barely moving, he had peed in his bed, he was shivering, and his body was hot to the touch. We rushed him to a nearby emergency animal hospital where they told us he had a fever of 106 degrees. At first, the vets there seemed unsure of what might be ailing Bodhi, but after taking X-rays of his legs, they eventually arrived upon a diagnosis of HOD.

Joint problems
Bodhi’s X-Rays

Hypertrophic Osteodystrophy is a bone disease that afflicts fast-growing, large breed dogs. It usually shows up when the puppies are two-to-four months old. Weimaraners, Irish Setters, Boxers, German Shepherd Dogs, and Great Danes are the dogs most commonly afflicted. Lameness is the primary manifestation of the disease; but Weimaraners and Irish Setters can display a variety of other symptoms. (For more, check out the Weimaraner Club of America. )

Bodhi was treated with a non-steroidal anti-inflammatory drug (NSAID) called Rimadyl and a pain killer, Tramadol. This is the common treatment for most dogs who get mild, uncomplicated cases of HOD. After two days in the hospital Bodhi was released and seemed largely okay. He was limping a bit, but that cleared up over the course of the next few days. Our initial research online did not indicate to us that HOD was “different” for Weimaraners and the vets at the hospital did not tell us that HOD was of particular concern for Weims. We were encouraged when we learn that once afflicted dogs’ initial growth spurts ended, they disease went away.

We contacted our breeder and she referred us to the handbook she gave us when we picked up Bodhi. It noted HOD research that had been done a decade earlier. (That is, out-of-date!) We investigated further and soon discovered articles about Dr. Noa Safra’s work at the UC Davis College of Veterinary Medicine. We also contacted the Weimaraner Club of America and spoke to a member of their health committee. She confirmed that Dr. Safra is a recognized expert in HOD.

We didn’t need any encouraging. We reached out to Dr. Safra immediately. She provided us with a complete overview of HOD in Weims. She told us how it affects Weimaraners more profoundly than other dogs. She said she had devised a special medical regimen that included Prednisone, not NSAIDs, to treat Weims. And she warned us to keep vigilant for any recurrence of the disease. She said, if left untreated, it could be fatal.

Bodhi did well for about a month and then, out of the blue, he got sick again. This time with diarrhea and a bad cough. We took him to our vet and she prescribed some medicine for the cough and advised us to observe him closely. A few days later the cough worsened and he had started limping again. As the day wore on, he lay completely still. Mucus was pouring out of his eyes and nose. If you touched him, he whimpered in pain.

We took him again to the hospital. The emergency room vet there diagnosed him with pneumonia and determined that his HOD had indeed flared up again. Again they prescribed NSAIDs and painkillers. This worried us, we knew from our research he needed to be on Prednisone. We shared Dr. Safra’s work about treating HOD-afflicted Weims with immuno-suppresive doses of Pred with this vet, but he said we couldn’t put Bodhi on the medicine because he had pneumonia. He said a dose of Pred that high would make the pneumonia worse.

Bodhi in the Hospital
Bodhi in the Hospital

We appealed to a second veterinarian at the hospital with whom we had a closer relationship, Dr. Christina Moore. Dr. Moore called Dr. Safra who advised that we needed to get Bodhi on Pred as soon as possible and that the medicine would clear up the pneumonia, which was HOD-related. After some back and forth with the hospital staff, Bodhi was finally weaned off the NSAIDs and given Prednisone. He spent three nights in the hospital. (Note: Dr. Moore has since become Urban Dog’s resident health expert. Check out some interviews with her here, here, and here.)

Bodhi’s recovery took some time. He couldn’t walk at all for about a week after being discharged from the hospital. Eventually he got up, but his legs were so weak and painful that walking was clearly very difficult for him. The video below shows Bodhi a few weeks after his last hospitalization. If you look closely you can see his front paws look almost like flippers. You can also see how difficult it was for him to walk. That was about as fast as he could go for a long time.

We worked with him over the next few months using physical therapy, and slowly, but surely his legs got stronger.

The biggest problem was every time we tried to lower the dose of the Pred, he’d start to show indications of a flare up (one of the earliest signs with Bodhi was a green discharge from his eyes.) But persistence and patience finally paid off. After many, many weeks, he was walking pretty well and we were finally able to take him off the Prednisone.

Below are “before” and “after” pictures of his front legs, which were hit hardest by the disease. On the left, you can see how knobby the joints were, that his wrists had no strength, and that his paws laid almost flat on the ground. You can see on the right that his legs are now far less lumpy and that he’s largely resting on his toes as he should. His legs are still short for a Weimaraner, but that doesn’t seem to be to be slowing him down at all.

Bodhi and Hypertrophic Osteodytrophy
Before and After

As I was writing this post, I asked Doctor Safra a question I had avoided years earlier: “Just how sick was Bodhi?”

She responded: “Bodhi was a ‘nine’ on a one-to-ten scale. ‘Ten’ would be pups who by the age of two or three are dead due to complications.”

Ugh. I’m glad I didn’t know that at the time.

Here is a video of Bodhi about a year after he went off Pred.


To finish, we’ll offer some advice. (I wrote this about HOD, but I think it’s good advice to take when dealing with any of your dog’s health issues.)

1. Do your homework! Make sure you read everything you can about HOD and Weims. Make sure your sources of information are reputable. Consult experts with verifiable credentials and experience with HOD in Weimaraners.

2. Make sure your family veterinarian does his or her homework! I don’t want to fault some of the vets we saw for not knowing about Weim-specific diseases, but if you are reading this, you are aware of the problem. Make sure your doctor is too. Advocate for your dog with your vet. If we had not pressed, I don’t think it’s unrealistic to say that Bodhi could’ve died during his second hospitalization.

3. Be patient. This is probably the hardest part. It was truly horrible seeing Bodhi so sick. But we knew that he’d eventually get through it.

4. Stay the course! Be diligent about administering the medicine and keep a close eye on your dog for any changes for the worse. Relapses are common in severe cases of HOD.

5. Be very careful when consulting “Dr. Google!” Dr. Google is not a veterinarian. There’s a lot of misleading and even outright wrong information on the internet concerning HOD. Talk to the experts: Weimaraner breeders, the Weimaraner Club of America, specialists at your regional veterinary teaching hospital, and acknowledged experts like Dr. Safra

6. And finally, shower your Weim with all the love you can. They are the best dogs ever! (I admit I am biased!) Dogs are only with us a short while. Make it the best time you can.

Here’s a picture of a happy and healthy Bodhi five years after HOD, living the good life!

Bodhi and Hypertrophic Osteodystrophy

If you want to follow Bodhi’s progress, check out his Instagram: Urbandognyc.

PS. This post is working! Here’s an email from a reader:

Hi Sean

Your story about Bodhi is so beautiful and really gives an insight that the case studies and vets don’t convey.
My pup Harvey is 5 months old has just been diagnosed with HOD – so far he has responded well to NSAIDs. However I have a suspicion that his second bout of illness wasn’t as responsive as the first, so I definitely need to get better informed and in touch with Dr Safra. Thank you for passing on her details.
Anyway so lovely to see the pictures of Bodhi alive and looking well. You can see Harvey on instagram @howzit_harvey if you like 🙂
Warmest regards



1 comment

  1. Our names are Sandra and Joe. We acquired our Boxer pup, Jack, about 2 months ago when he was 12 weeks. At 4 months, Joe noted him less active one evening. Next morning, did not get off the couch all morning. At noon I recognized something wrong re: his affect, and took his temp. It was 105.7°. Took him in as an Emergency. Vet kept him overnight, gave IV fluids, antibiotics and Deramaxx, an NSAID. Next day better, we took him home late afternoon with Amoxicillin, Deramaxx. Fever had broken night before; as long as it stayed normal with fluids he could be home. Late that night, fever up again, 105.8°. Returned to vets, where he was hospitalized for next 5 days. Our vet consulted with an Internist friend . She recommended joint tap for bacterial culture. We had done several CBC work ups, nothing specific to point to any one disease, so auto immune disorders were suspected – but there are two that the vet suggested. One is Hypertrophic Osteo Dystrophy; the other Immune Mediated Poly Arthritis. Both present with similar symptoms. An expert radiologist read our vet’s xrays, and the 2nd set showed changes to him in the growth plate. The joint culture was negative for bacterial infection, thus HOD became the primary diagnosis. The IMPA diagnosis, in our case, is still a concurrent secondary diagnosis because Jack was right in the timeline for an allergic reaction to his distemper shots. It is rare to have both, but it is not ruled out yet. With the long hospitalization, the vet replaced the Deramaxx after a sufficient time with Prednisone. Jack’s temp stayed about 103-104° thru the time period off Deramaxx before the Prednisone could be given. He was also on IV antibiotics and morphine. Three of Jack’s limbs were afflicted…we have our first follow up visit on 4th Sept 2018. One of our problems: Jack has been peeing a great deal , this is due to the Prednisone. We have used pads because at first, he was as surprised as we were when he couldn’t hold his water well. Before all this he was almost housebroken as long as someone was paying attention. We began to use the joint support vitamins, Fromm’s Large Breed puppy kibble from Wisconsin ( bought at Agway), high grade wet food, and pain medicine, half strength. Jack is on about 5 different meds. We are a month into this and 4000.00 poorer!! Lol! URGE anyone to obtain pet insurance from day 1 of ownership- we hemmed and hawed and none of this and any related problems will ever be covered. Pet Insurance IS NOT expensive. Will update Jack’s progress as it occurs. Sandra C.

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